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We investigated the susceptibility to antibacterials of streptococci isolated from 8 medical facilities in Gifu prefecture between 2005 and 2007. Strains used in this study include 118 of Group A streptococci, 89 of Group B streptococci, and 58 of group G streptococci. For Group A streptococci, cefteram and imipenem gave the lowest MIC90 at 0.0078 microg/mL, followed by cefditoren and cefcapene at 0.0156 microg/mL and penicillin G, amoxicillin and meropenem at 0.0313 microg/mL. For Group B streptococci, cefteram, cefditoren, cefcapene and imipenem gave the lowest MIC90 at 0.0313 microg/mL, followed by penicillin G and meropenem at 0.0625 microg/mL and amoxicillin at 0.125 microg/mL. For Group G streptococci, cefteram and imipenem gave the lowest MIC90 at 0.0078 microg/mL, followed by penicillin G, cefditoren, cefcapene and meropenem at 0.0156 microg/mL and amoxicillin at 0.0313 microg/mL. With Group A and B streptococci, the susceptibility data obtained in this study were compared with those of strains between 2000 and 2001. As for group A streptococci, the MIC50 and MIC90 of beta-lactam agents were about the same as those of previous study, however the MIC90 of quinolones increased about 2.5-fold and resistant strains were found. As for Group B streptococci, the MIC50 and MIC90 of almost all of the antibacterials were about the same as those of the previous study, however the MIC90 of clarithromycin increased about 10-fold, indicating that the resistant strains are widely spread.
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Patients presenting with tonsillopharyngitis, sinusitis or pneumonia were randomized to receive either of the test drugs provided they clinically qualified for empirical clarithromycin treatment. The study endpoints were clinical and bacteriological cure rates, tolerability and safety. The study was designed to test for non-inferiority with regard to cure rates.
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There is currently conflicting level 1 evidence in the use of long-term antibiotics for chronic rhinosinusitis without nasal polyps. The primary aim of this feasibility study was to optimise future randomised trial design by assessing recruitment and retention of patients alongside providing preliminary data on symptomatic control.
To clarify the role of MMPs regulated by CAM in the progression of myocarditis. Design CAM was given to experimental rats with autoimmune myocarditis (EAM) from day -7 to day 21 (early treated group, n=6) or from day 1 to day 21 (late treated group, n=6) twice a day.
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Eradication of Helicobacter pylori cures and prevents the relapse of duodenal ulceration and also results in histological resolution of chronic active gastritis.
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Of 51 specimens, 41 (80.39%) showed positive results in bacteria culture. The antibiotic susceptibility was as follows: vancomycin-100%, moxifloxacin-100%, levofloxacin-92.31%, rifampin-90.91%, ciprofloxacin-81.58%, SMZ-TMP-67.65%, azithromycin-47.62%, clarithromycin-45.00%, ampicillin sodium and sulbactam sodium-35.90%, cefatriaxone-39.39%, cefuroxime sodium-30.43%, penicillin-8.33%.
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PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma.
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On an intention-to-treat basis. H. pylori infection was cured in 77% (95% CI: 65-88%) of patients. Minor side-effects including diarrhoea, nausea and taste disturbance were reported by 64% of patients. Ninety-five per cent of patients consumed > 95% of tablets. Metronidazole resistance was 29% but all cultures were sensitive to amoxycillin and clarithromycin.
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To test whether one week's triple therapy with omeprazole and two antibiotics is enough to induce healing of a peptic (gastric and/or duodenal) ulcer.
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Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough level in human and feline organ transplant patients. However, the interaction of CLM with CsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM on the pharmacokinetics of CsA in three healthy beagles were investigated. The treatments included CsA 10 mg/kg alone and CsA 10 mg/kg + multiple-dose of CLM 10 mg/kg. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of CLM may decrease the required CsA dosage in CsA-based immunosuppressive therapy in renal transplanted dogs.