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Noroxin (Norfloxacin)
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Noroxin

Noroxin is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones). Noroxin fights bacteria in the body. Noroxin is used to treat bacterial infections of the prostate and urinary tract. Noroxin also treats gonorrhea. Noroxin may also be used for purposes not listed in this medication guide.

Other names for this medication:
Alenbit, Ambigram, Amicrobin, Apiflox, Apirol, Asudufe, Azo uroflam, Baccidal, Bacfamil, Bacteriotal, Bactracid, Bafurokisaru, Barazan, Barocul, Basteen, Baxicin, Bexinor, Bio tarbun, Biscolet, Blemalart, Chibroxin, Chibroxine, Chibroxol, Co norfloxacin, Constilax, Danilon, Diperflox, Effectsal, Epinor, Esclebin, Espeden, Firin, Flobarl, Flocidal, Flossac, Flox, Floxamed, Floxamicin, Floxatral, Floxatrat, Floxen, Floxinol, Fluseminal, Foxgoria, Grenis, Gyrablock, H-norfloxacin, Janacin, Lemorcan, Lexiflox, Lexinor, Lorcamin, Loxone, Mariotton, Memento nf, Menorox, Microxin, Mitatonin, N-flox, Naflox, Nalion, Negaflox, Negalflex, Niterat, Noflo, Nofloxan, Nofocin, Nofxan, Nolicin, Noprose, Nor, Noracin, Norax, Noraxin, Norbactin, Norcozine, Norfacin, Norfen, Norflodal, Norflogen, Norflohexal, Norflok, Norflol, Norflomax, Norflosal, Norilet, Normax, Norocin, Noroxine, Norsol, Norzen, Notler, Noxacin, Nufloxib, Oranor, Ovinol, Parcetin, Pharex norfloxacin, Pistofil, Quinabic, Renor, Renoxacin, Respexil, Rexacin, Ritromine, Sebercim, Senro, Setanol, Shinun, Sinobid, Sofasin, Stbanil, Taflox, Theanorf, Trizolin, Unasera, Uricin, Uriflox, Uritracin, Uroflox, Urofos, Uronovag, Uroquin, Uroseptal, Urospes-n, Urotem, Uroxacin, Utibid, Uticina, Utinor, Vefloxa, Vetamol, Wenflox, Xaflor, Xasmun, Zoroxin

Similar Products:
Cipro, Levaquin, Quixin, Tequin, Avelox, Ocuflox

 

Also known as:  Norfloxacin.

Description

Noroxin comes as a tablet to take by mouth. It is usually taken twice a day for 3 to 28 days. The length of treatment depends on the type of infection being treated. Your doctor will tell you how long to take Noroxin. Take Noroxin at around the same times every day and try to space your doses 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Noroxin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Take Noroxin at least 1 hour before or 2 hours after meals or after drinking milk or eating dairy products.

Swallow the tablets with a full glass of water.

You should begin to feel better during the first few days of your treatment with Noroxin. If your symptoms do not improve or if they get worse, call your doctor.

Take Noroxin until you finish the prescription, even if you feel better. Do not stop taking Noroxin without talking to your doctor unless you experience certain serious side effects listed in the IMPORTANT WARNING or SIDE EFFECT sections. If you stop taking Noroxin too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Noroxin is also sometimes used to treat certain infections of the stomach and intestines. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Dosage

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Noroxin with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent crystals from forming in the urine.

Take Noroxin on an empty stomach 1 hour before or 2 hours after eating a meal, drinking milk, or eating a dairy product such as yogurt or cheese.

If you are being treated for gonorrhea, your doctor may also have you tested for syphilis, another sexually transmitted disease.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Noroxin will not treat a viral infection such as the common cold or flu.

Overdose

If you overdose Generic Noroxin and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Noroxin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Taking norfloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Also tell your doctor if you have ever had any tendon problems during or after your treatment with norfloxacin or another quinolone or fluoroquinolone antibiotic. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), or prednisone (Sterapred). If you experience any of the following symptoms of tendinitis, stop taking norfloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking norfloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area.

Taking norfloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take norfloxacin. If you have myasthenia gravis and your doctor tells you that you should take norfloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Talk to your doctor about the risks of taking norfloxacin.

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Oligo(epsilon-caprolactone) and oligolactide were synthesized via ring-opening polymerization of cyclic esters in the presence of creatinine as initiators. Thus obtained oligomers were successfully used in the synthesis of novel polyurethane conjugates of norfloxacin. The structures of the polymers and conjugates were elucidated by means of MALDI-TOF MS, NMR and IR studies.

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In this paper, pressurized CEC was used for the separation and determination of seven fluoroquinolones (FQs). The effect of different experimental conditions, such as the concentration and pH of the buffer, the organic modifier concentration, the surfactant and ion-paring agents added to the electrolyte, and applied voltage were studied. All the seven FQs were baseline separated using mobile phase containing 27% v/v ACN, 5 mmol/L Na2HPO4 buffer (pH 4.0 adjusted using citric acid), 11 mmol/L SDS, and 0.01% TEA v/v at detection wavelength of 287 nm and at an applied voltage of -10 kV. The calibration curves were linear (r>0.9991) over a concentration range of 1.0-50.0 mg/L for norfloxacin (NFLX); 2.5-50.0 mg/L for fleroxacin (FLX), ciprofloxacin (CPFX), and lomefloxacin (LMX); and 5.0-50.0 mg/L for enoxacin (ENX), ofloxacin (OFLX), and gatifloxacin (GFLX). The detection limits (S/N = 3) for ENX, OFLX, FLX, NFLX, CPFX, LMX, and GFLX were 0.5, 0.8, 0.4, 0.2, 0.4, 0.5, and 1.0 mg/L, respectively. The method is simple, rapid, and reproducible. It was successfully applied to the analysis of fish muscle samples spiked with FQs. Mean recoveries ranged from 81.6 to 97.6%.

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Earlier studies have reported very high (120 to 2,700 mg/kg) concentrations of norfloxacin in feces after therapeutic doses. MICs for fecal microorganisms are with few exceptions far below these levels. Nevertheless, clinical investigations show that the main part of the aerobic gram-positive and the anaerobic microflora remains unaffected after norfloxacin administration. In this study, the binding of [14C]norfloxacin to fecal material was analyzed. The binding of a group of nonlabeled quinolones to feces and the interactions between Enterococcus faecium, Bacteroides fragilis, and norfloxacin were also investigated. The results showed that norfloxacin has the ability to bind to feces. The specific binding was reversible, saturated after 90 min of incubation at 37 degrees C, and increased linearly with fecal concentration. Scatchard plots and nonlinear regression computer analyses revealed two different binding classes. The primary specific binding had a dissociation constant (KD) of 1.0 microM and a maximal binding capacity (Bmax) of 0.12 mumol/g of feces. The KD and Bmax of the secondary, more unspecific binding were 450 microM and 11.8 mumol/g of feces, respectively. The binding of unlabeled ciprofloxacin, enoxacin, ofloxacin, pefloxacin, and norfloxacin to feces was comparable to that of [14C]norfloxacin. The results of norfloxacin binding to suspensions of B. fragilis suggested that the main part of the binding is to the bacterial fraction of feces. In the presence of 8.0 g (dry weight) of B. fragilis per liter, the MBC of norfloxacin for E. faecium increased from 8 to 256 micrograms/ml. The finding of the present study indicated that binding of norfloxacin to feces may explain the paradox of high fecal concentrations of norfloxacin versus the actual effect on the normal gastrointestinal microflora.

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buy noroxin 2017-09-26

The data buy noroxin will be useful in monitoring surface waters for forecasting and management of waterborne outbreaks.

where to buy noroxin 2015-06-18

Sixty clinical isolates of M. tuberculosis, 24 susceptible and 36 resistant to conventional primary antituberculous drugs, were tested against four fluoroquinolones (ciprofloxacin, ofloxacin, pefloxacin and norfloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentration (MIC) of 0.6 mg/l or less to all strains tested. Strains resistant to isoniazid and other antitubercular drugs also showed more or less equal MICs for these two drugs. Mycobacterium tuberculosis H37 Rv showed MIC < 0.6 mg/l on each occasion. Other agents viz., norfloxacin and pefloxacin showed lesser activity against all these strains tested in comparison Buy Generic Amoxicillin Online to ciprofloxacin and ofloxacin.

buy noroxin online 2016-07-30

The efficacy and tolerability of brodimoprim OD versus norfloxacin BID were studied in patients affected by bacterial urinary tract infections. The study was performed in 203 patients divided into two parallel randomized groups orally given either brodimoprim 400 mg OD on the first day followed by 200 mg OD for 2 days, or norfloxacin 400 mg BID respectively. The efficacy of treatment Buy Clarithromycin Online was evaluated by the bacterial cultures, tolerability, analysis of signs and symptoms, a complete physical examination and from laboratory data. The results showed that brodimoprim and norfloxacin in the majority of patients resulted in a reduction of fever and symptoms caused by the infective process. Of the 103 patients enrolled in the brodimoprim OD group, 99 had a complete course of therapy with a positive outcome. There was only one case of failed treatment and 3 cases which could not be evaluated because of voluntary interruption of treatment. Of the 100 patients treated with norfloxacin BID, 94 completed therapy with a positive clinical outcome and there were 4 cases of treatment failure. Thus the efficacy of brodimoprim OD appears comparable to that of norfloxacin BID in the treatment of urinary tract infections.