Also known as:
Terramycin is a product of the metabolism of Streptomyces rimosus and is one of the family of
Terramycin antibiotics. A 1 percent solution in water is acidic (pH about 2.5). Its potency is
affected in solutions more acid than pH 2 and it is rapidly destroyed by alkali hydroxides.
Terramycin diffuses readily through the placenta into the fetal circulation, into the pleural
fluid and, under some circumstances, into the cerebrospinal fluid. It appears to be concentrated in the
hepatic system and excreted in the bile, so that it appears in the feces, as well as in the urine, in a
biologically active form.
Inert ingredients in the formulation are: glucosamine hydrochloride; hard gelatin capsules (which may
contain Red 3, Yellow 10 and other inert ingredients); magnesium stearate; sodium lauryl sulfate;
Adults: Usual daily dose, 1–2 g divided in four equal doses, depending on the severity of the
For children above eight years of age: Usual daily dose, 10–20 mg per pound (25–50 mg/kg) of body
weight divided in four equal doses.
Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.
For treatment of brucellosis, 500 mg Terramycin four times daily for 3 weeks should be
accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the
For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used
for the treatment of both males and females in the following divided dosage schedule: 1.5 grams
followed by 0.5 gram q.i.d. for a total of 9.0 grams.
For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days
should be given. Close follow-up, including laboratory tests, is recommended.
Administration of adequate amounts of fluid along with capsule and tablet forms of drugs in the
tetracycline class is recommended to wash down the drugs and reduce the risk of esophageal irritation
Concomitant therapy: Antacids containing aluminum, calcium, or magnesium impair absorption and should
not be given to patients taking oral tetracyclines.
Food and some dairy products also interfere with absorption. Oral forms of tetracyclines should be
given 1 hour before or 2 hours after meals. Pediatric oral dosage forms should not be given with milk
formulas and should be given at least 1 hour prior to feeding.
In patients with renal impairment. Total dosage should be decreased by reduction of recommended
individual doses and/or by extending time intervals between doses.
In the treatment of streptococcal infections, a therapeutic dose of Terramycin should be
administered for at least 10 days.
If you overdose Generic Tetracycline and you don't feel good you should visit your doctor or health
care provider immediately. Symptoms of Generic Terramycin overdosage: retching, diarrhoea, nausea.
Store Terramycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep away
from heat, moisture, and light. Do not store in the bathroom. Keep Terramycin out of the reach of
children and away from pets.